Some of the toxicological concerns associated with GLP-1 receptor agonists include the potential risk of pancreatitis, pancreatic cancer, and thyroid C-cell tumors. The risk of pancreatitis has been a point of contention, with some studies suggesting a potential link, while others have found no significant increase in risk. Animal studies have shown an association between GLP-1 RAs and thyroid C-cell tumors, but this has not been conclusively demonstrated in humans.
