Yes, NATs are implicated in the carcinogenesis process, particularly in the context of aromatic amine-induced cancers. Aromatic amines are found in tobacco smoke, dyes, and some industrial chemicals. NAT-mediated acetylation of these compounds can produce reactive intermediates that bind to DNA, causing mutations and initiating cancer. The risk of developing cancer from exposure to these compounds can be influenced by the individual's NAT2 genotype.
