While Annex V serves an essential function, there are some controversies regarding its application. One concern is the potential for overlooking risks associated with exempt substances, particularly if new scientific data emerges about their toxicological profiles. Additionally, the criteria for exemption may not always keep pace with evolving scientific understanding, leading to debates over whether certain substances should remain exempt. As such, ongoing review and potential revisions to Annex V may be necessary to ensure continued protection of human health and the environment.