Are There Any Genetic Disorders Associated with the Pentose Phosphate Pathway?
Yes, genetic disorders such as Glucose-6-phosphate dehydrogenase deficiency (G6PD deficiency) affect the PPP's normal functioning. G6PD is the first enzyme of the oxidative phase of the PPP. Its deficiency can lead to insufficient NADPH production, making cells, especially red blood cells, more susceptible to oxidative damage from certain drugs, foods, and infections.
