What Happens if the Pentose Phosphate Pathway is Impaired?
Impairment of the PPP can lead to a decreased supply of NADPH, compromising the cell's ability to handle oxidative stress. This can result in increased oxidative damage, particularly in red blood cells, leading to conditions like hemolytic anemia. Additionally, a compromised PPP can affect the synthesis of nucleotides, impacting DNA repair and replication processes, which are crucial during toxic exposure.
