Are There Any Limitations to Epigenomic Studies in Toxicology?
While epigenomic studies have advanced our understanding of toxicological mechanisms, they are not without limitations. One challenge is distinguishing causative epigenetic changes from those that are merely correlative. Additionally, the complexity and variability of the epigenome pose difficulties in establishing standardized methods for epigenetic analyses. Furthermore, while some epigenetic changes are reversible, others can be stable and persistent, complicating the interpretation of toxicological studies.
