Yes, beta lactam antibiotics can cause non-allergic toxic effects, particularly at high doses or in patients with renal impairment. These include:
Neurotoxicity: High doses can lead to seizures, especially in patients with decreased renal function or pre-existing neurological conditions. Hematologic effects: Leukopenia, thrombocytopenia, and hemolytic anemia have been reported, often with prolonged therapy. Gastrointestinal disturbances: Diarrhea, nausea, and vomiting can occur, sometimes due to alteration of gut flora.
