Yes, several natural toxins target microtubules. For example, colchicine, derived from the autumn crocus plant, binds to tubulin and inhibits microtubule polymerization. This property makes it useful in treating gout, but also poses risks of toxicity if not used properly. Additionally, podophyllotoxin from the mayapple plant disrupts microtubule assembly and is a precursor for certain anticancer drugs.
