Can Environmental Factors Affect Procaspase Activity?
Yes, environmental factors can significantly affect procaspase activity. Exposure to environmental toxins, such as heavy metals, pesticides, and organic pollutants, can alter the apoptotic pathways by modulating procaspase activation. For instance, certain toxins may induce oxidative stress, leading to the activation of the intrinsic pathway, while others may mimic natural ligands, triggering the extrinsic pathway.
