What are the implications of Fas (CD95) in autoimmune diseases?
In autoimmune diseases, the regulation of Fas-mediated apoptosis is often disrupted. Abnormal Fas signaling can lead to the survival of autoreactive lymphocytes, cells that attack the body's own tissues. This mechanism is implicated in conditions such as systemic lupus erythematosus (SLE) and rheumatoid arthritis. Understanding Fas interactions in these diseases provides insights into potential therapeutic interventions aimed at restoring normal apoptotic processes.
