Yes, while hydrolytic enzymes are crucial for detoxification, they can also contribute to toxicity under certain conditions. For example, the hydrolysis of specific compounds can lead to the formation of toxic intermediates. One such instance is the bioactivation of certain prodrugs, where the enzymatic activity produces a toxic metabolite instead of a therapeutic one. Additionally, genetic polymorphisms in hydrolytic enzyme genes can lead to variations in enzyme activity, influencing individual susceptibility to toxins.
