What is the Role of Hydrolytic Enzymes in Drug Metabolism?
Hydrolytic enzymes play a pivotal role in the metabolism of various drugs. They are responsible for the initial phase of drug metabolism, often referred to as Phase I metabolism. During this phase, drugs undergo chemical modification, primarily through hydrolysis, oxidation, or reduction. This modification is essential for the subsequent conjugation reactions (Phase II metabolism) that further enhance drug solubility for excretion.
