Yes, neutrophils can contribute to toxicity, particularly when their response is excessive or uncontrolled. The release of ROS and proteolytic enzymes, while intended to combat pathogens, can also damage host tissues. This phenomenon is observed in conditions such as acute respiratory distress syndrome (ARDS) and certain autoimmune diseases. In toxicology, understanding this dual role of neutrophils is important in assessing the potential risks associated with exposure to harmful substances.
