Several factors can affect the permeability of the intercellular route:
Molecular Size: Larger molecules may find it more challenging to pass through tight junctions. Charge and Polarity: Charged or polar molecules may face difficulties in crossing cellular barriers. Lipophilicity: Lipophilic substances tend to traverse cellular membranes more easily. Pathological Conditions: Conditions like inflammation can alter tight junctions, affecting permeability.
