Can NPC1 Mutations Influence Susceptibility to Environmental Toxins?
Yes, mutations in the NPC1 gene can indeed affect an individual's susceptibility to environmental toxins. The impaired ability to manage lipid and cholesterol levels within cells can alter cell membrane integrity and function, potentially increasing vulnerability to toxins that target these cellular structures. Additionally, the buildup of cholesterol and other lipids may affect the cellular defense mechanisms, making cells less able to cope with toxic insults.
