Research has suggested potential links between NPC1 dysfunction and cancer. Abnormal lipid metabolism, a hallmark of NPC1 deficiency, is also a characteristic of many cancer cells, which often rely on altered lipid pathways for growth and survival. While a direct causal relationship has not been fully established, the mechanisms of lipid trafficking influenced by NPC1 may play a role in tumorigenesis or cancer progression. Understanding these links could open new avenues for therapeutic interventions.
