Yes, the RfD can change as new scientific data becomes available. Advances in toxicological research and improved understanding of chemical effects can lead to revisions of existing RfDs. Regulatory agencies regularly review and update RfDs to reflect the latest scientific knowledge and ensure continued protection of public health.
In summary, the reference dose is a fundamental component of toxicological risk assessment, providing a basis for evaluating the safety of chemical exposures. Understanding its determination, application, and limitations is essential for protecting human health in a world continually influenced by chemical substances.
