How Do PBPK Models Differ from Traditional Models?
Traditional pharmacokinetic models often use empirical data to describe the kinetics of chemicals, which can be limited by the need for extensive experimental data. In contrast, PBPK models are based on the mechanistic approach and rely on physiological data, allowing for more detailed and scalable predictions across different species and exposure scenarios. This makes PBPK models particularly useful for extrapolation between species, such as from animals to humans, and for predicting outcomes in different population groups.
