The link between CFTR and toxicology arises from its role in the body's defense mechanisms against toxins. CFTR is involved in the transport of glutathione, a pivotal antioxidant that helps in detoxification and protection against oxidative stress. Dysfunctional CFTR can lead to impaired glutathione transport, increasing susceptibility to oxidative damage and toxic insults. Additionally, CFTR influences the pharmacokinetics of drugs and chemicals, affecting their absorption, distribution, metabolism, and excretion.
