cystic fibrosis transmembrane conductance regulator (cftr)

How Does CFTR Affect Drug Metabolism?

CFTR impacts drug metabolism by modulating the activity and expression of various drug-metabolizing enzymes. For instance, alterations in CFTR activity can affect the expression of cytochrome P450 enzymes, which are crucial for the metabolism of numerous drugs. This interaction can lead to altered drug efficacy and toxicity, necessitating careful consideration of CFTR status in pharmacotherapy.

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