ADME processes are studied using various approaches, including in vitro models, in vivo studies in animals, and human clinical trials. Advanced techniques such as mass spectrometry and imaging technologies help in tracking substances within the body. Computational modeling and simulations are becoming increasingly important for predicting ADME behaviors without extensive animal testing. These studies provide crucial data for understanding the kinetics of toxic substances and for regulatory safety evaluations.
By understanding the processes of absorption, distribution, metabolism, and excretion, toxicologists can better predict and mitigate the harmful effects of chemical exposures. This knowledge is vital for developing effective safety guidelines and therapeutic interventions to protect human health and the environment.
