absorption, distribution, metabolism, and excretion

Why is Metabolism Important?

Metabolism, primarily occurring in the liver, transforms substances into more water-soluble compounds for easier excretion. This process can either detoxify a harmful chemical or convert a relatively harmless substance into a more toxic one, known as bioactivation. Metabolism involves phase I reactions (modifications like oxidation) and phase II reactions (conjugation with another substance). Understanding metabolic pathways is essential for predicting the duration and intensity of toxic effects.

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