Antidepressants, particularly tricyclic antidepressants (TCAs) and selective serotonin reuptake inhibitors (SSRIs), can be toxic in overdose. TCAs can cause cardiac arrhythmias, seizures, and anticholinergic effects, while SSRIs may lead to serotonin syndrome. Management involves supportive care, activated charcoal, and specific antidotes like sodium bicarbonate for TCA toxicity.
