Determining set tolerances involves a multi-step process:
Toxicity Testing: Chemicals undergo extensive toxicological testing to identify their potential adverse effects. This includes acute, sub-chronic, and chronic studies. Risk Assessment: Data from toxicity tests are used to perform risk assessments, which estimate the likelihood and severity of adverse health effects in humans. Safety Margins: Safety margins are applied to account for uncertainties and variability in human populations. This ensures that the set tolerances are protective of all individuals. Regulatory Review: Regulatory agencies review the data and risk assessments to establish MRLs that are legally enforceable.
