How Can Allosteric Activation Contribute to Toxic Effects?
Conversely, allosteric activation involves the enhancement of protein activity through effector binding. In toxicology, this can result in overactive pathways, potentially leading to harmful outcomes. For example, some pesticides act as allosteric activators of acetylcholinesterase, causing excessive accumulation of acetylcholine and leading to overstimulation of neural pathways.
