What is the Role of Allosteric Inhibition in Toxicity?
Allosteric inhibition occurs when an effector molecule binds to an allosteric site and decreases the activity of the protein. This type of modulation can lead to toxic effects when critical pathways are inhibited. For example, heavy metals like lead and mercury can allosterically inhibit enzymes involved in neurotransmitter synthesis, contributing to neurotoxicity.
