Mitigating the effects of interfering substances is essential for obtaining accurate toxicological results. Some strategies include:
Method optimization: Adjusting assay conditions, such as pH, temperature, or reagent concentrations, can reduce interferences. Use of alternative methods: If one assay is prone to interference, alternative methods or technologies, such as LC-MS/MS, may provide more accurate results. Sample dilution: Diluting samples can reduce the concentration of interfering substances to a level where they no longer affect the assay. Consultation with experts: Collaborating with assay manufacturers or toxicology experts can provide insights into managing specific interferences.
