Several strategies can be employed to identify interfering substances in toxicological analyses:
Sample pretreatment: Techniques such as filtration, centrifugation, or solid-phase extraction can be used to remove potential interferents before analysis. Use of controls: Including positive and negative controls in assays can help identify unexpected interferences. Spiking experiments: Adding known concentrations of potential interferents to samples can help assess their impact on the assay. Advanced analytical techniques: Methods like mass spectrometry or chromatography can separate and identify interfering substances.