The study of p53 in toxicology involves several applications, one of which is using p53 status as a biomarker for assessing the carcinogenic potential of chemicals. Researchers can evaluate the impact of specific agents on p53 activity or measure the induction of p53-regulated genes as indicators of cellular stress. Moreover, p53 knockout or mutant animal models are invaluable tools for understanding how the loss of p53 function influences susceptibility to toxicants and the development of cancer.
