How Can Pharmacogenetics Inform Clinical Practice?
In clinical practice, pharmacogenetic testing can inform drug selection and dosing, helping to avoid adverse drug reactions. For instance, patients undergoing treatment with warfarin can benefit from genetic testing for VKORC1 and CYP2C9 polymorphisms to determine the optimal dose, minimizing the risk of bleeding complications. Similarly, genetic testing for HLA alleles can predict hypersensitivity reactions to drugs like abacavir and carbamazepine.
