What are Some Key Examples of Pharmacogenetic Variations?
One well-documented example is the variation in the CYP2D6 gene, which affects the metabolism of drugs like codeine and tamoxifen. Individuals with reduced CYP2D6 activity may experience poor drug efficacy or increased toxicity. Similarly, the TPMT gene influences the metabolism of thiopurine drugs used in cancer therapy. Patients with low TPMT activity are at higher risk for myelosuppression, a severe toxic response.
