Metabolism is a critical factor in determining the toxicity of a substance, and 3D structures play a vital role in this process. The stereochemistry of molecules can influence their interaction with metabolic enzymes, such as cytochrome P450, which are responsible for the biotransformation of xenobiotics. Enzymatic activity can vary depending on the configuration of the substrate, affecting the rate and pathway of metabolism. This can lead to different metabolites, some of which may be more or less toxic than the parent compound.
