When alkalies come into contact with biological tissues, they can cause significant damage due to their corrosive nature. Alkaline exposure primarily affects the skin, eyes, and respiratory system. Upon skin contact, they can cause severe burns, dehydration, and necrosis. Eye exposure can lead to corneal damage and potential blindness. Inhalation of alkaline fumes or dust can cause respiratory irritation, coughing, and in severe cases, pulmonary edema.