Genetic variation can profoundly impact how individuals respond to toxins. Specific gene polymorphisms can alter the function of enzymes involved in detoxification pathways. For example, variations in the GST (Glutathione S-transferase) gene can affect the detoxification of carcinogens, potentially influencing cancer risk. Similarly, polymorphisms in the NAT2 (N-acetyltransferase 2) gene can affect how drugs and environmental chemicals are metabolized, altering toxicity levels.