individual susceptibility

How Does Genetic Variation Affect Susceptibility?

Genetic variation can profoundly impact how individuals respond to toxins. Specific gene polymorphisms can alter the function of enzymes involved in detoxification pathways. For example, variations in the GST (Glutathione S-transferase) gene can affect the detoxification of carcinogens, potentially influencing cancer risk. Similarly, polymorphisms in the NAT2 (N-acetyltransferase 2) gene can affect how drugs and environmental chemicals are metabolized, altering toxicity levels.

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