How Do Genetic Factors Influence Xenobiotic Metabolism?
Genetic variations play a crucial role in the efficiency of xenobiotic metabolism. Polymorphisms in genes encoding metabolic enzymes can lead to variability in the metabolic rates among individuals, affecting drug efficacy and toxicity. For instance, the CYP2D6 enzyme is known to have multiple genetic variants that can classify individuals as poor, intermediate, extensive, or ultra-rapid metabolizers.
