How Do Genetic Variants Affect Toxicological Responses?
Genetic variants can alter the function of metabolic enzymes, transporters, and receptors, which are critical in the detoxification and elimination of toxins. For example, polymorphisms in genes encoding cytochrome P450 enzymes can lead to variations in drug metabolism rates, affecting both therapeutic efficacy and the risk of adverse effects. Individuals with specific genetic variants may metabolize drugs too quickly or too slowly, leading to toxicity or therapeutic failure.
