How Do Genetic Variations Affect Influx Transporters?
Genetic polymorphisms in genes encoding influx transporters can lead to interindividual variability in transporter function, influencing drug response and toxicity. Such variations can alter the expression or activity of transporters, affecting the pharmacokinetics of drugs and the susceptibility to toxic effects. Understanding these genetic differences is important for personalized medicine, as it allows for the tailoring of drug therapies based on an individualâs genetic makeup.
