Influx transporters can significantly affect the toxicodynamic and toxicokinetic profiles of various compounds. By modulating the cellular entry of toxicants, these transporters can either exacerbate or mitigate toxic effects. For instance, high expression of a particular influx transporter in a target organ can lead to increased accumulation of a toxic compound, thereby enhancing its toxic effects. Conversely, low expression can result in decreased uptake and toxicity.
