GPCRs can modulate toxicity through various mechanisms. When a toxicant binds to a GPCR, it can trigger a cascade of intracellular events that lead to toxic responses. For example, overstimulation of GPCRs can lead to cytotoxicity, while desensitization of these receptors can alter cellular responses. Additionally, GPCRs can interact with other cellular targets, potentially leading to synergistic or antagonistic effects.
