HCFCs are typically not acutely toxic to humans at low exposure levels. However, exposure to high concentrations can lead to adverse health effects such as dizziness, headache, and respiratory irritation. Inhalation of HCFCs in confined spaces can displace oxygen, leading to asphyxiation. Chronic exposure may result in liver and kidney damage. Despite their low acute toxicity, their long-term environmental impact necessitates careful handling.