HLA alleles can impact drug metabolism by affecting how the immune system recognizes and processes drugs or their metabolites. Certain alleles are associated with adverse drug reactions (ADRs), which can lead to severe toxicity. For example, the HLA-B*57:01 allele is linked to hypersensitivity reactions to the antiretroviral drug abacavir. Identifying these genetic markers can help in predicting individuals' risk of ADRs and guide personalized medicine approaches.
