Inducers work by interacting with nuclear receptors, such as the Aryl Hydrocarbon Receptor (AhR), the Pregnane X Receptor (PXR), and the Constitutive Androstane Receptor (CAR). Upon binding to these receptors, inducers activate transcription factors that upregulate the expression of genes encoding for detoxification enzymes, including various CYP450 isoforms. This process ultimately increases the rate at which the body metabolizes and clears foreign compounds.
