What role does P-glycoprotein play in multidrug resistance?
P-glycoprotein is a key player in the development of multidrug resistance (MDR) in cancer therapy. By actively removing chemotherapeutic agents from cancer cells, P-gp reduces their intracellular concentrations, leading to decreased drug efficacy and treatment failure. This resistance mechanism is a significant challenge in oncology, necessitating the development of P-gp inhibitors or alternative therapeutic strategies to overcome MDR.
