MAOIs have a high potential for drug interactions. Some notable interactions include:
Tyramine-Rich Foods: Foods like aged cheese, cured meats, and fermented products can trigger hypertensive crises when consumed with MAOIs. Serotonergic Drugs: Combining MAOIs with SSRIs, SNRIs, or other drugs that increase serotonin levels can lead to serotonin syndrome. Sympathomimetic Agents: These include over-the-counter decongestants and stimulants, which can also precipitate hypertensive crises. Other Antidepressants: Switching from an MAOI to another type of antidepressant requires a washout period to avoid dangerous interactions.
