Mechanistic models work by simulating the various biological pathways and interactions that occur following exposure to a toxicant. For example, a model may include steps such as absorption, distribution, metabolism, and excretion (ADME) of the substance. It may also incorporate data on the [toxicokinetics](#) and [toxicodynamics](#) of the compound, which describe how the body processes the toxin and how the toxin affects the body, respectively. Advanced models may also incorporate genetic and environmental factors that influence susceptibility to toxicity.
