PBPK models are comprised of several key components:
Compartments: Represent different body tissues and organs, each with specific physiological characteristics. Parameters: Include anatomical, physiological, and chemical-specific data, such as blood flow rates, tissue volumes, and partition coefficients. Equations: Differential equations that describe the kinetics of chemical distribution and transformation within the compartments. Data Inputs: Experimental data and literature values that inform the parameters and model assumptions.
