PCBs are known to have a range of toxic effects on human health. They have been linked to several adverse effects, including potential carcinogenicity, immune system suppression, reproductive and developmental toxicity, and endocrine disruption. Chronic exposure to PCBs can result in skin conditions, such as chloracne, and may affect the liver, leading to liver damage or cancer. The International Agency for Research on Cancer (IARC) has classified PCBs as probable human carcinogens.