Recreational drugs can affect the body by altering the normal functioning of the brain and various physiological systems. For instance, stimulants like cocaine and methamphetamine increase heart rate and blood pressure by enhancing the release of neurotransmitters such as dopamine and norepinephrine. Conversely, depressants like opioids and alcohol can slow down brain activity, leading to sedation and potentially respiratory depression. Psychoactive substances like cannabis and hallucinogens primarily affect perception, mood, and cognition.