Regulatory agencies assess safety through a comprehensive review of toxicological data. This includes evaluating studies on absorption, distribution, metabolism, and excretion (ADME) of substances, as well as their potential to cause carcinogenicity, mutagenicity, and reproductive toxicity. Agencies also consider exposure scenarios, which involve assessing how and to what extent humans may be exposed to a substance. This holistic approach ensures that all aspects of potential risk are considered.
