Researchers use various approaches to study the microenvironment:
3D Cell Culture Models: These models better mimic the in vivo environment by allowing cells to grow in three dimensions, incorporating ECM components and simulating biochemical gradients. Microfluidic Systems: These devices enable precise control over the cellular microenvironment, allowing researchers to study cellular responses to dynamic changes in conditions. Animal Models: Despite their limitations, animal models remain a valuable tool for studying the complex interactions within the microenvironment and their impact on toxicology.
